1. Ultrasound in Medical Technology
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  5. BCC300 set (Bubble Counter for microbubble detection)

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Article No. VK-30300

BCC300 set (Bubble Counter for microbubble detection)

Ultrasonic Doppler device for the non-invasive monitoring and documentation of microbubble activity during extracorporeal circulation, incl. two ultrasonic probes of your choice (3/8″, 1/2″, 1/4″), complete set


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The BCC300 – THE GOLD STANDARD FOR AIR BUBBLE ANALYSIS DURING ECC – is a precise measuring system for the non-invasive monitoring and documentation of microbubble activity during extracorporeal circulation. Using latest Doppler ultrasound measuring technique the accurate analysis of the particle size distribution in the blood of the ECC is possible. Its outstanding precision in measuring size, number and volume of microbubbles  can help to improve the quality of the extracorporeal circulation and single components of the HLM.

The continuous advance in perfusion technology – especially bypass systems miniaturisation – is very demanding for safety functions. In this connection, BCC300 outperforms by far conventional bubble detection systems through its precision and flexibility. BCC300 monitors simultaneously the venous and arterial ECC line by use of advanced technologies. They detect smallest gas embolisms (micro bubbles) that occur typically in arterial line subsequently to filter just as precisely as big gas activities (bolus) in venous line.
In addition, BCC300 is able to transform each embolism event into an acoustic signal for the determination of micro bubbles in size and volume. This makes available an alarm function that clearly reduces the embolism risk by the early detection of gas contamination.
BCC300 can be integrated into all heart-lung-machines without problems.
All embolism events are automatically logged during surgery and can be subsequently evaluated directly at the device. For this purpose, BCC300 can be extended to a convenient PC workstation in few steps. The measure dates analysis allows a detailed assessment of all embolism-relevant surgery activities. The course of events can be considerably optimised this way for the benefit of patient safety.
The measuring data documentation forms an essential part of perfusion report. For this reason, BCC300 offers a program package that equally supports data evaluation and documentation. Additionally, the data can be exported to all standard programs (e.g. Excel) or for external archiving.
Targeted measurements of individual ECC components result in further improvement of perfusion systems and setup.
The gas embolism management by means of BCC300 represents the safest way to careful patient treatment and embolism-poor perfusion!


Publications with regard to GAMPF’s medical technology (PDF, 142 KB, 7. May 2018).

• Stehouwer, M.
Gaseous microemboli reduction during cardiopulmonary bypass: Impact of extracorporeal circuit design
Academisch Proefschrift. Universiteit van Amsterdam, Faculteit der Geneeskunde. Amsterdam: Marco Stehouwer

• Segers, T., Stehouwer, M. C., de Somer, F. M. J. J., de Mol, B. A., Versluis, M.
Optical verification and in-vitro characterization of two commercially available acoustic bubble counters for cardiopulmonary bypass systems
Perfusion. 2018 Jan, Vol. 33(1), pp. 16-24
PMID: 28766987 . PMCID: PMC5734373 . DOI: 10.1177/0267659117722595

• Stehouwer, M. C., de Vroege, R., Hoohenkerk, G. J. F., Hofman, F.N., Kelder, J.C., Buchner, B., de Mol, B. A., Bruins, P.
Carbon dioxide flush of an integrated minimized perfusion circuit prior to priming prevents spontaneous air release into the arterial line during clinical use
Artif Organs. 2017 Nov, Vol. 41(11), pp. 997-1003
PMID: 28741663. DOI: 10.1111/aor.12909

• Stehouwer, M. C., Legg, K. R., de Vroege, R., Kelder, J. C., Hofman, E., de Mol, B. A., Bruins, P.
Clinical evaluation of the air-handling properties of contemporary oxygenators with integrated arterial filter
Perfusion. 2017 Mar, Vol. 32(2), pp. 118-125
PMID: 27516417. DOI: 10.1177/0267659116664402

• Born, F., Chen, J., Thierfelder, N., Günther, S., Peterß, S., Hagl, C., König, F.
Microbubble activity during extra corporeal life support
Presentation. DGTHG: ECC and Myocardial Protection, Feb 12, 2017
Thorac cardiovasc Surg. 2017, Vol. 65(S 01), S1-S110
DOI: 10.1055/s-0037-1598758

• Herbst, D. P.
Effects of purge-flow rate on microbubble capture in radial arterial-line filters
J Extra Corpor Technol. 2016 Sep, Vol. 48(3), pp. 105-112
PMID: 27729703 PMCID: PMC5056680

• Stehouwer, M. C., de Vroege, R., Kelder, J. C., Hofman, F. N., de Mol, B. A., Bruins, P.
Effect of oxygenator size on air removal characteristics: a clinical evaluation
ASAIO J. 2016 Jul-Aug, Vol. 62(4), pp. 421-6
PMID: 26919180. DOI: 10.1097/MAT.0000000000000360

• Nygaard, K., Thiara, A. S., Tronstad, C., Ringdal, M. A., Fiane, A. E.
VAVD vacuum may cause bubble transgression in membrane oxygenators
Perfusion. 2016 May 25, Vol. 31(8), pp. 648-652
PMID: 27226328. DOI: 10.1177/0267659116651345

• Ens, E., Haimerl, G., Halbe, M., Dreher, E. C., Dreizler, T., Münch, F.
Bubble-Elimination über einen externen arteriellen Filter: State-of-the-Art?
KARDIOTECHNIK (German Journal of Perfusion). 4/2015

• Wagner, S., Rode, C., Wojke, R., Canaud, B.
Observation of microbubbles during standard dialysis treatments
Clin Kidney J. 2015 Aug, Vol. 8(4), pp. 400-404
PMID: 26251706. PMCID: PMC4515906. DOI: 10.1093/ckj/sfv051

• Born, F., Günther, S., Khaladj, N., Schramm, R., Bagaev, E., Hagl, C.
Avoidance of airembolism during extra corporal life support (ECLS)
Congress Fee. 44th Annual GSTCVS meeting, Freiburg, 2015
Thorac cardiovasc Surg. 2015 Jan, Vol. 63(S 01), ePP96
DOI: 10.1055/s-0035-1544592

• Simons, A. P., Martens, E. G., Ganushchak, Y. M., Weerwind, P. W.
Centrifugal pump performance during low-flow extracorporeal CO2 removal; safety considerations.
Perfusion. 2015 Jan, Vol. 30(1), pp. 17-23
PMID: 24919405. DOI: 10.1177/0267659114540024

• Born, F., Günther, S., Khaladj, N., Hagl, C.
Luftembolie unter Extra Corporeal Life Support (ECLS) Therapie
Congress Fee. 43rd International Annual Meeting of German Perfusionist, Nürnberg, Nov 2014
Abstracts: PDF

• Azzolina, S., Cavalucci, A.
Evaluation of air handling capability in the new A.L.ONE oxygenators with integrated cascade aterial filter
Congress Fee. 14th European Conference on Perfusion Education and Training, Milan, Oct 2014

• Hella, D.
In vitro comparison of 3 types of oxygenators during the priming procedure using pulsatile flow
Congress Fee. 14th European Conference on Perfusion Education and Training, Milan, Oct 2014

• Stehouwer, M. C., Kelder, J. C., van Oeveren, W., de Vroege, R.
In vitro air removal characteristics of two neonatal cardiopulmonary bypass systems: filtration may lead to fractionation of bubbles
Int J Artif Organs. 2014 Sep, Vol. 37(9), pp. 688-696
PMID: 25262633. DOI: 10.5301/ijao.5000348

• Johagen, D., Appelblad, M., Svenmarker, S.
Can the oxygenator screen filter reduce gaseous microemboli?
J Extra Corpor Technol. 2014 Mar, Vol. 46(1), pp. 60-66
PMID: 24779120. PMCID: PMC4557512

• Milano, A. D., Dodonov, M., Onorati, F., Menon, T., Gottin, L., Malerba, G., Mazzucco, A., Faggian, G.
Pulsatile flow decreases gaseous micro-bubble filtering properties of oxygenators without integrated arterial filters during cardiopulmonary bypass
Interact Cardiovasc Thorac Surg. 2013 Nov, Vol. 17(5), pp. 811-817
PMID: 23842758. PMCID: PMC3805187. DOI: 10.1093/icvts/ivt264

• Potger, K. C., McMillan, D., Ambrose, M.
Microbubble transmission during cardiotomy infusion of a hardshell venous reservoir with integrated cardiotomy versus a softshell venous reservoir with separated cardiotomy: an in vitro comparison
J Extra Corpor Technol. 2013 Jun, Vol. 45(2), pp. 77-85
PMID: 23930376. PMCID: PMC4557584

• Herbst, D. P.
The effects of pressure on gases in solution: possible insights to improve microbubble filtration for extracorporeal circulation
J Extra Corpor Technol. 2013 Jun, Vol. 45(2), pp. 94-106
PMID: 23930378. PMCID: PMC4557586

• Dodonov, M., Milano, A., Onorati, F., Dal Corso, B., Menon, T., Ferrarini, D., Tessari, M., Faggian, G., Mazzucco, A.
Gaseous micro-emboli activity during cardiopulmonary bypass in adults: pulsatile flow versus nonpulsatile flow
Artif Organs. 2013 Apr, Vol. 37(4), pp. 357-367
PMID: 23489040. DOI: 10.1111/aor.12000

• Haines, D. E., Stewart, M. T., Dahlberg, S., Barka, N. D., Condie, C., Fiedler, G. R. , Kirchhof, N. A., Halimi, F., Deneke, T.
Microembolism and catheter ablation I: a comparison of irrigated radiofrequency and multielectrode-phased radiofrequency catheter ablation of pulmonary vein ostia
Circ Arrhythm Electrophysiol. 2013 Feb, Vol.6(1), pp. 16-22
PMID: 23392585. DOI: 10.1161/CIRCEP.111.973453

• Maier, S., Scherer, C., Schmidt, F.,Prassek, S.,Klemm, R.,Kiss, J.,Benk, C.,Beyersdorf, F.
Optimization of micro bubble elimination by the use of an oxygenator with an integrated arterial filter in combination with the dynamic bubble trap
Thorac cardiovasc Surg. 2013 Jan, Vol. 61(S 01), P50
DOI: 10.1055/s-0032-1332690

• Simons, S. P., Lancé, M. D., Ganushchak, Y. M., Weerwind, P. W.
Hypovolämie während der extrakorporalen Kreislaufunterstützung kann zu Entgasung und arteriellen Mikroblasen führen
KARDIOTECHNIK (German Journal of Perfusion). 1/2013, pp. 3-8
Journal: PDF

• Scheer, M. M., Münch, F., Bohn, S., Haimerl, G., Weyand, M., Harig, F.
Oxygenator-Leistungsvergleich: Compactflo Evolution Phisio M versus Inspire 6 M Phisio
KARDIOTECHNIK (German Journal of Perfusion). 1/2013, pp. 9-17
Journal: PDF

• Herbst, D. P., Najm, H. K.
Development of a new arterial-line filter design using computational fluid dynamics analysis
J Extra Corpor Technol. 2012 Sep;44(3):139-44
PMID: 23198394. PMCID: PMC4557525

• Myers, G. J.
Gaseous Microemboli during Cardiopulmonary Bypass
Indian Journal of Extra-Corporeal Technology. 2012, Volume : 22, Issue : 1, 13-16

• Stehouwer, M. C., Boers, C., de Vroege, R., Kelder, J. C., Yilmaz, A., Bruins, P.
Clinical evaluation of the air removal characteristics of an oxygenator with integrated arterial filter in a minimized extracorporeal circuit
Int J Artif Organs. 2011 Apr, Vol. 34(4), pp. 374-382
PMID: 21534248. DOI: 10.5301/IJAO.2011.7749

• Kana, A., Benk, C., Maier, S., Ebberink, J., Schlenksak, C., Beyersdorf, F.
Vergleich eines neuen Oxygenators mit integriertem arteriellen Filter vs. baugleichen Oxygenator ohne integrierten arteriellen Filter mit dynamischer Blasenfalle
Z Herz- Thorax- Gefäßchir. 2011 Oct, Vol. 25(5), p. 305
DOI: 10.1007/s00398-011-0880-8

• Bakker, E. W. M., Visser, K.
An in vitro comparison of bubble elimination in quadrox and capiox oxygenators
NeSECC UPTODATE 2011 nr. 1; p.20-27

• Roosenhoff, T. P., Stehouwer, M. C., de Vroege, R., Butter, R. P., Van Boven, W. J., Bruins P.
Air removal efficiency of a venous bubble trap in a minimal extracorporeal circuit during coronary artery bypass grafting
Artif Organs. 2010 Dec, Vol. 34(12), pp. 1092-1098
PMID: 20545664. DOI: 10.1111/j.1525-1594.2009.00986.x

• De Somer, F. M. J. J., Vetrano, M. R., Van Beeck, J. P., Van Nooten, G. J.
Extracorporeal bubbles: a word of caution
Interact Cardiovasc Thorac Surg. 2010 Jun, Vol. 10(6), pp. 995-1001
PMID: 20197351. DOI: 10.1510/icvts.2009.229088

• Jirschik, M., Keyl, C., Beyersdorf, F.
A clinical comparison of bubble elimination in Quadrox and Polystan oxygenators
Perfusion. 2009 Nov, Vol. 24(6), pp. 423-427
PMID: 20093338. DOI: 10.1177/0267659109358206

• Wang, S., Ündar, A.
Vacuum-assisted venous drainage and gaseous microemboli in cardiopulmonary bypass
J Extra Corpor Technol. 2008 Dec, Vol. 40(4), pp. 249-256
PMID: 19192754. PMCID: PMC4680714

• Nielsen, P. F., Funder, J. A., Jensen, M. Ø., Nygaard, H.
Influence of venous reservoir level on microbubbles in cardiopulmonary bypass
Perfusion. 2008 Nov, Vol. 23(6), pp. 347-353
PMID: 19454563. DOI: 10.1177/0267659109104954

• Schmidt, S., Philipp, A., Thrum, A., Gietl, M., Foltan, M., Arlt, M., et al. (2007)
Mikroblasenaktivität in miniaturisierten EKZ-Systemen
KARDIOTECHNIK (German Journal of Perfusion). 1/2007, pp. 8-12
Journal: PDF

• Kutschka, I.,Schönrock, U.,El-Essawi, A., Pahari, D., Anssar, M.,Harringer, W.
A new minimized perfusion circuit provides highly effective ultrasound controlled deairing
Artif Organs. 2007 Mar, Vol. 31(3), pp. 215-220
PMID: 17343697. DOI: 10.1111/j.1525-1594.2007.00367.x

• Brand, S., Klaua, R., Dietrich, G., Schultz, M.
P2L-4 Ultrasonic detection and quantitative analysis of microscopic bubbles and particles in solution: Enhanced by attenuation compensation
2006 IEEE Ultrasonics Symposium, pp. 1840-1843
DOI: 10.1109/ULTSYM.2006.470

• Stock U. A., Müller T., Bienek R., Krause H., Hartrumpf M., Albes J.
Deairing of the venous drainage in standard extracorporeal circulation results in a profound reduction of arterial micro bubbles
Thorac Cardiovasc Surg. 2006 Feb, Vol. 54(1), pp. 39-41
PMID: 16485187. DOI: 10.1055/s-2005-865874

• Perthel, M., Kseibi, S., Sagebiel, F., Alken, A., Laas, J.
Comparison of conventional extracorporeal circulation and minimal extracorporeal circulation with respect to microbubbles and microembolic signals
Perfusion. 2005 Oct, Vol. 20(6), pp. 329-333
PMID: 16363318. DOI: 10.1191/0267659105pf828oa

• Schmidt, V., Kanig, R., Tugtekin, S. M., Knaut, M., Matschke, K.
Die Entstehung, Bedeutung und Vermeidung von Mikrobläschen in den verschiedenen Formen des EKZ-Managements
KARDIOTECHNIK (German Journal of Perfusion). 2004, Suppl. 1, p. 17
Journal: PDF

• Mathias, G.
Neuropsychologisches Outcome nach Koronarer Bypass-Operation unter Anwendung einer neuartigen Dynamischen Luftfalle (dynamic bubble trap)
Dissertation. Justus-Liebig-Universität Gießen, Fachbereichs Humanmedizin
DNB idn: 969802064

• Jenderka, K. V., Schultz, M., Dietrich, G., Fornara, P.
Detection and sizing of micro bubbles in streaming fluids with ultrasound
SENSORS, 2002. Proceedings of the IEEE, Vol. 1, pp. 528-531
DOI: 10.1109/ICSENS.2002.1037151

• Jenderka, K.-V., Dietrich, G., Cobet, U., Kopsch, B., Klemenz, A., Urbanek, P.
Detection of micro bubbles in the extracorporeal circulation
Ultrasonics Symposium, 1998. Proceedings., 1998 IEEE, Vol. 2, pp. 1819-1822
DOI: 10.1109/ULTSYM.1998.765304

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